🧪 Hypotheses

3 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

3

Total Hypotheses

190

Validated

0.72

Avg Score

0.59

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (1)mechanistic (0)diagnostic (0)methodological (0)

Sort: Score Feasibility Novelty Impact Newest

combination 0.80

CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Window Identification

🧬 sTREM2/membrane-TREM2/ADAM10 🏥 neuroimmunology 📖 10🏛 1

✅ 0.85 ✨ 0.60 💥 0.88

## Mechanistic Overview...

combination 0.70

Granzyme B Inhibition with Serpina3n to Preserve Axonal Integrity Against Cytotoxic Attack

🧬 GZMB 🏥 neuroimmunology 📖 11🏛 1

✅ 0.38 ✨ 0.65 💥 0.68

## Mechanistic Overview...

therapeutic 0.67

TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

🧬 TREM2/ACAT1/LXR 🏥 neuroimmunology 📖 8🏛 2

✅ 0.55 ✨ 0.65 💥 0.72

## Mechanistic Overview...

All 3 hypotheses loaded