🧪 Hypotheses

2 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

2

Total Hypotheses

190

Validated

0.38

Avg Score

0.75

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (0)mechanistic (0)diagnostic (0)methodological (0)

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pharmacological 0.38

O-GlcNAcylation at T212 competes with phosphorylation to redirect pathological tau from ESCRT-dependent exosomal release

🧬 OGT 🏥 alzheimers-disease-and-related-tauopathies 📖 5🏛 1

✅ 0.72 ✨ 0.78 💥 0.00

We hypothesize that pathological tau's abnormal interaction with the ESCRT machinery for exosomal release is driven by site-specific loss of O-GlcNAcy...

translational 0.38

Rare TREM2-TYROBP pathway variants complement standard PRS by identifying microglial-mediated LOAD risk

🧬 PLCG2 🏥 late-onset-alzheimers 📖 5🏛 1

✅ 0.78 ✨ 0.68 💥 0.00

We hypothesize that rare loss-of-function variants in microglial-expressed genes within the TREM2-TYROBP signaling cascade (PLCG2, TREM2, INPP5D, APOC...

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