🧪 Hypotheses

7 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

7

Total Hypotheses

190

Validated

0.61

Avg Score

0.55

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (0)mechanistic (7)diagnostic (0)methodological (0)

Sort: Score Feasibility Novelty Impact Newest

mechanistic 0.83

IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface

🧬 IL6R, IL6 🏥 neuroinflammation 📖 29🏛 1

✅ 0.72 ✨ 0.65 💥 0.80

## Mechanistic Overview...

mechanistic 0.78

PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocytes

🧬 PDE4A, PDE4B, PDE4D 🏥 neuroinflammation 📖 13🏛 1

✅ 0.62 ✨ 0.58 💥 0.75

## Mechanistic Overview...

mechanistic 0.74

Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determines AQP4 Tolerance Fate

🧬 AHR, IL10, TNFRSF13B, TIGIT, FOXP3 🏥 neuroinflammation 📖 12🏛 1

✅ 0.60 ✨ 0.85 💥 0.72

**Molecular Mechanism and Rationale**...

mechanistic 0.55

SYK-Independent TREM2 Pathways Remain Functional in TYROBP Deficiency

🧬 SYK, TREM2 🏥 neuroinflammation 📖 7🏛 1

✅ 0.60 ✨ 0.65 💥 0.60

## Mechanistic Overview...

mechanistic 0.51

GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to Reduce Neuroinflammatory Cell Infiltration in Alzheimer's Dis

🧬 GAS6/TAM receptor complex 🏥 neuroinflammation 📖 9🏛 1

✅ 0.42 ✨ 0.80 💥 0.62

## Mechanistic Overview...

mechanistic 0.45

TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocytic Clearance

🧬 TREM2 (Triggering receptor expressed on myeloid cells 2) + SYK (spleen tyrosine kinase) 🏥 neuroinflammation 📖 11🏛 1

✅ 0.50 ✨ 0.60 💥 0.55

## Mechanistic Overview...

mechanistic 0.42

Complement Cascade Activation Bridges Microglial OxPC Sensing to Synaptic Vulnerability

🧬 C1QA, C3, C3AR1 (complement cascade) 🏥 neuroinflammation 📖 11🏛 1

✅ 0.38 ✨ 0.58 💥 0.40

## Mechanistic Overview...

All 7 hypotheses loaded