🧪 Hypotheses

4 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

4

Total Hypotheses

190

Validated

0.56

Avg Score

0.48

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (4)mechanistic (0)diagnostic (0)methodological (0)

Sort: Score Feasibility Novelty Impact Newest

therapeutic 0.60

STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-I Feedback Looping

🧬 TMEM173 (STING) 🏥 neuroinflammation 📖 10🏛 1

✅ 0.52 ✨ 0.82 💥 0.78

## Mechanistic Overview...

therapeutic 0.59

TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance

🧬 TREM2 🏥 neuroinflammation 📖 7🏛 1

✅ 0.50 ✨ 0.80 💥 0.60

## Mechanistic Overview...

therapeutic 0.56

Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senescent Microglia to Prevent SASP-Driven Complement Cascade Ampl

🧬 CDKN2A (p16^Ink4a), CDKN1A (p21^Cip1/Waf1) 🏥 neuroinflammation 📖 10🏛 1

✅ 0.58 ✨ 0.70 💥 0.80

## Mechanistic Overview...

therapeutic 0.51

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Function by Suppressing IL-1β-Mediated Inflammatory Damage

🧬 TYRO3 🏥 neuroinflammation 📖 10🏛 1

✅ 0.32 ✨ 0.88 💥 0.55

## Mechanistic Overview...

All 4 hypotheses loaded