🧪 Hypotheses

11 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

11

Total Hypotheses

190

Validated

0.64

Avg Score

0.59

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (0)mechanistic (11)diagnostic (0)methodological (0)

Sort: Score Feasibility Novelty Impact Newest

mechanistic 0.96

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

🧬 GRIN2B 🏥 neuroscience 📖 30🏛 4

✅ 0.85 ✨ 0.78 💥 0.82

## Mechanistic Overview...

mechanistic 0.95

Cortico-Striatal Synchrony Restoration via NMDA Modulation

🧬 GRIN2B 🏥 neuroscience 📖 15🏛 3

✅ 0.78 ✨ 0.34 💥 0.80

**Molecular Mechanism and Rationale**...

mechanistic 0.94

Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment

🧬 MAPT 🏥 neuroscience 📖 17🏛 3

✅ 0.77 ✨ 0.56 💥 0.79

**Molecular Mechanism and Rationale**...

mechanistic 0.67

Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Signaling

🧬 TREM2 🏥 neuroscience 📖 18🏛 3

✅ 0.00 ✨ 0.00 💥 0.00

## **Molecular Mechanism and Rationale**...

mechanistic 0.56

GluN2B-Mediated Microglial Activation and Tau Propagation

🧬 GRIN2B 🏥 neuroscience 📖 19🏛 3

✅ 0.00 ✨ 0.45 💥 0.00

## Mechanistic Overview...

mechanistic 0.56

Ketone-Primed Thalamocortical Enhancement of Glymphatic Tau Clearance

🧬 GRIN2B 🏥 neuroscience 📖 19🏛 3

✅ 0.00 ✨ 0.45 💥 0.00

## Mechanistic Overview...

mechanistic 0.54

TREM2-GluN2B Circuit: Microglial Control of Thalamocortical Oscillations and Glymphatic Tau Clearance

🧬 TREM2 🏥 neuroscience 📖 19🏛 3

✅ 0.40 ✨ 0.55 💥 0.63

## Mechanistic Overview...

mechanistic 0.52

TREM2-Dependent Microglial Control of Thalamocortical-Glymphatic Tau Clearance

🧬 TREM2 🏥 neuroscience 📖 19🏛 3

✅ 0.47 ✨ 0.50 💥 0.51

## Mechanistic Overview...

mechanistic 0.49

GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling

🧬 GRIN2B 🏥 neuroscience 📖 19🏛 3

✅ 0.47 ✨ 0.50 💥 0.47

## Mechanistic Overview...

mechanistic 0.48

GluN2B-Mediated Perivascular Pericyte Control of Glymphatic Tau Clearance

🧬 GRIN2B 🏥 neuroscience 📖 19🏛 3

✅ 0.40 ✨ 0.50 💥 0.47

## Mechanistic Overview...

mechanistic 0.38

GluN2B-Mediated Microglial Activation and Tau Phagocytosis

🧬 GRIN2B 🏥 neuroscience 📖 19🏛 3

✅ 0.00 ✨ 0.00 💥 0.00

This hypothesis proposes that GluN2B-containing NMDA receptors on microglia directly regulate tau protein clearance through enhanced phagocytic activi...

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