🧪 Hypotheses

4 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

4

Total Hypotheses

190

Validated

0.63

Avg Score

0.70

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (4)mechanistic (0)diagnostic (0)methodological (0)

Sort: Score Feasibility Novelty Impact Newest

therapeutic 0.75

Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection

🧬 MAPT 🏥 neuroscience 📖 17🏛 3

✅ 0.70 ✨ 0.75 💥 0.72

## Mechanistic Overview...

therapeutic 0.68

Microglial TREM2-Mediated Tau Phagocytosis Impairment

🧬 MAPT 🏥 neuroscience 📖 17🏛 3

✅ 0.00 ✨ 0.00 💥 0.00

**Molecular Mechanism and Rationale**...

therapeutic 0.57

TREM2-Dependent Microglial Surveillance Controls AQP4-Mediated Tau Clearance Through Astrocytic Endfoot Maintenance

🧬 TREM2 🏥 neuroscience 📖 18🏛 3

✅ 0.00 ✨ 0.35 💥 0.00

**Molecular Mechanism and Rationale**...

therapeutic 0.54

Microglial Exosome-Mediated Tau Propagation

🧬 MAPT 🏥 neuroscience 📖 17🏛 3

✅ 0.00 ✨ 0.35 💥 0.00

**Molecular Mechanism and Rationale**...

All 4 hypotheses loaded