🧪 Hypotheses

7 hypotheses generated by SciDEX — searchable by gene, disease, or keyword

7

Total Hypotheses

190

Validated

0.54

Avg Score

0.69

Avg Feasibility

Validated Hypotheses

190 hypotheses have passed validation gates and now form the scientific closure set.

API

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocam

Score 0.97 Evidence 0.00 3 debates 1 predictions

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

GRIN2B neuroscience

Score 0.96 Evidence 0.20 4 debates 5 predictions

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent am

PVALB alzheimers

Score 0.96 Evidence 0.40 3 debates 1 predictions

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Score 0.95 Evidence 0.00 2 debates 1 predictions

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables Longitudinal Neur

Score 0.94 Evidence 0.20 1 debates 2 predictions

All therapeutic (0)mechanistic (7)diagnostic (0)methodological (0)

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mechanistic 0.75

Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate

🧬 C3, C3aR, NFKB1, PPARGC1A 🏥 alzheimers-disease-parkinsons 📖 8🏛 1

✅ 0.50 ✨ 0.50 💥 0.50

## Mechanistic Overview...

mechanistic 0.70

CD8+ T-Cell Perforin Pathway as Driver of Neuronal Pyramid Loss

🧬 GZMB, PRF1, HLA-E, NKG2D 🏥 alzheimers-disease-parkinsons 📖 5🏛 1

✅ 0.50 ✨ 0.50 💥 0.50

## Mechanistic Overview...

mechanistic 0.66

m6A Hypermethylation of SNCA mRNA Stabilises Alpha-Synuclein Transcript and Promotes Lewy Pathology

🧬 SNCA 🏥 parkinson 📖 5🏛 1

✅ 0.65 ✨ 0.72 💥 0.80

N6-methyladenosine (m6A) hypermethylation of SNCA mRNA in substantia nigra dopaminergic neurons stabilises the transcript, increases alpha-synuclein p...

mechanistic 0.53

Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid raft microdomain formation, impairing LIMP

🧬 GBA 🏥 parkinsons 📖 5🏛 1

✅ 0.81 ✨ 0.68 💥 0.00

We propose that GBA deficiency-driven accumulation of glucosylceramide (GlcCer) in lysosomal membranes creates ordered lipid raft-like microdomains th...

mechanistic 0.38

Glucosylceramide-mediated feedback loop drives GBA-synuclein pathology

🧬 GBA1 🏥 parkinsons 📖 5🏛 1

✅ 0.75 ✨ 0.68 💥 0.00

In GBA-associated PD, reduced glucocerebrosidase activity leads to glucosylceramide accumulation in neurons and glia, which directly promotes α-synucl...

mechanistic 0.38

Heparan sulfate proteoglycan binding selectivity determines misfolded protein transmission efficiency

🧬 SDC3 (Syndecan-3) 🏥 alzheimers-disease-parkinsons-disease-als 📖 5🏛 1

✅ 0.78 ✨ 0.71 💥 0.00

Differential intercellular transmission efficiency of misfolded proteins (tau, α-synuclein, TDP-43) is determined by their distinct conformational epi...

mechanistic 0.38

H2S/butyrate imbalance drives enteric alpha-synuclein pathology via TLR4 signaling

🧬 SNCA 🏥 parkinsons 📖 5🏛 1

✅ 0.82 ✨ 0.78 💥 0.00

In Parkinson's disease, elevated H2S-producing Desulfovibrio species and depleted butyrate-producing Faecalibacterium prausnitzii create a metabolite ...

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