🧪 Hypotheses

therapeutic 0.00

Alpha-theta entrainment therapy to enhance default mode network coherence

🧬 SST 🏥 alzheimers 📖 57🏛 2

✅ 0.00 ✨ 0.00 💥 0.00

Alpha-theta entrainment therapy targets somatostatin (SST) interneurons to restore default mode network (DMN) coherence in Alzheimer's disease through...

therapeutic 0.00

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via SST interneuron disinhibition

🧬 SST 🏥 alzheimers 📖 65🏛 3

✅ 0.00 ✨ 0.00 💥 0.00

This intervention targets somatostatin-positive (SST) interneurons in the stratum oriens to restore hippocampal gamma oscillations through disinhibiti...

therapeutic 0.00

Closed-loop transcranial focused ultrasound with gamma entrainment to restore hippocampal-cortical synchrony via PV inte

🧬 PVALB 🏥 alzheimers 📖 65🏛 3

✅ 0.00 ✨ 0.00 💥 0.00

This hypothesis combines the precision of transcranial focused ultrasound (tFUS) targeting with gamma entrainment therapy to restore hippocampal-corti...

therapeutic 0.97

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations v

🧬 SST 🏥 alzheimers 📖 55🏛 3

✅ 0.00 ✨ 0.60 💥 0.00

## Mechanistic Overview...

therapeutic 0.96

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic d

🧬 PVALB 🏥 alzheimers 📖 61🏛 3

✅ 0.00 ✨ 0.50 💥 0.00

## Mechanistic Overview...

therapeutic 0.96

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore ento

🧬 SST 🏥 alzheimers 📖 50🏛 3

✅ 0.54 ✨ 0.85 💥 0.74

## Mechanistic Overview...

therapeutic 0.95

Gamma entrainment therapy to restore hippocampal-cortical synchrony

🧬 SST 🏥 alzheimers 📖 66🏛 2

✅ 0.88 ✨ 0.78 💥 0.80

## Mechanistic Overview...

therapeutic 0.91

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron ne

🧬 CCK 🏥 alzheimers 📖 61🏛 2

✅ 0.00 ✨ 0.64 💥 0.00

## Mechanistic Overview...

mechanistic 0.89

ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia

🧬 ACSL4 🏥 alzheimers 📖 56🏛 3

✅ 0.75 ✨ 0.85 💥 0.85

## Mechanistic Overview...

therapeutic 0.89

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization

🧬 BDNF 🏥 alzheimers 📖 11🏛 3

✅ 0.70 ✨ 0.82 💥 0.83

## Mechanistic Overview...

therapeutic 0.88

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance

🧬 SST 🏥 alzheimers 📖 57🏛 2

✅ 0.85 ✨ 0.82 💥 0.82

## Mechanistic Overview...

therapeutic 0.87

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption i

🧬 PVALB 🏥 alzheimers 📖 64🏛 2

✅ 0.86 ✨ 0.79 💥 0.80

## Mechanistic Overview...

therapeutic 0.87

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitm

🧬 PVALB 🏥 alzheimers 📖 68🏛 3

✅ 0.82 ✨ 0.78 💥 0.75

## Mechanistic Overview...

therapeutic 0.87

Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activation using implantable LED

🧬 PVALB 🏥 alzheimers 📖 68🏛 3

✅ 0.45 ✨ 0.78 💥 0.68

## Mechanistic Overview...

therapeutic 0.86

Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding i

🧬 PVALB 🏥 alzheimers 📖 67🏛 3

✅ 0.45 ✨ 0.85 💥 0.75

## Mechanistic Overview...

therapeutic 0.83

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic enhancement and amy

🧬 PVALB 🏥 alzheimers 📖 65🏛 2

✅ 0.55 ✨ 0.82 💥 0.78

## Mechanistic Overview...

therapeutic 0.83

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefronta

🧬 SST 🏥 alzheimers 📖 50🏛 3

✅ 0.35 ✨ 0.82 💥 0.78

## Mechanistic Overview...

unknown 0.83

Gamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaffer collateral plasticity

🧬 GRIN2A/GRIN2B (NR2A/NR2B NMDA receptors), CAMK2A 🏥 alzheimers 📖 12🏛 1

✅ 0.91 ✨ 0.62 💥 0.88

Auditory 40 Hz entrainment applied during NREM sleep consolidates temporal coupling between hippocampal theta oscillations (4-8 Hz) and cortical gamma...

therapeutic 0.82

Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation

🧬 BDNF 🏥 alzheimers 📖 77🏛 2

✅ 0.72 ✨ 0.68 💥 0.78

## Mechanistic Overview...

therapeutic 0.81

Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path i

🧬 PVALB 🏥 alzheimers 📖 58🏛 3

✅ 0.78 ✨ 0.76 💥 0.75

## Mechanistic Overview...

therapeutic 0.80

Dual-Receptor Antibody Shuttling

🧬 N/A 🏥 alzheimers 📖 10🏛 1

✅ 0.55 ✨ 0.34 💥 0.00

## Mechanistic Overview...

mechanistic 0.80

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease

🧬 ACSL4 🏥 alzheimers 📖 48🏛 4

✅ 0.60 ✨ 0.56 💥 0.00

## Mechanistic Overview...

mechanistic 0.80

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia

🧬 ACSL4 🏥 alzheimers 📖 45🏛 5

✅ 0.50 ✨ 0.63 💥 0.00

## Mechanistic Overview...

therapeutic 0.80

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma feedback to prevent tau p

🧬 PVALB 🏥 alzheimers 📖 50🏛 2

✅ 0.35 ✨ 0.92 💥 0.78

## Mechanistic Overview...

therapeutic 0.78

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophagy flux and degrade intra

🧬 SST 🏥 alzheimers 📖 58🏛 2

✅ 0.00 ✨ 0.66 💥 0.00

## Mechanistic Overview...

mechanistic 0.78

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter Degeneration in Alzheimer

🧬 ACSL4 🏥 alzheimers 📖 44🏛 4

✅ 0.60 ✨ 0.54 💥 0.00

## Mechanistic Overview...

therapeutic 0.78

APOE4-Specific Proteolytic Fragment Inhibition Therapy

🧬 APOE 🏥 alzheimers 📖 31🏛 1

✅ 0.45 ✨ 0.80 💥 0.70

## Mechanistic Overview...

unknown 0.78

Gamma entrainment reactivates PV+ interneuron ensembles to restore inhibition/excitation balance

🧬 PV+ interneuron populations; GABRA1, GABRA5 (GABA-A α1, α5 subunits); KCNJ9 (Kir3.1) 🏥 alzheimers 📖 0🏛 1

✅ 0.76 ✨ 0.58 💥 0.85

40 Hz auditory-visual gamma entrainment selectively activates parvalbumin-positive (PV+) basket cells in hippocampus and entorhinal cortex, strengthen...

mechanistic 0.78

LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Associated Microglia

🧬 LPCAT3 🏥 alzheimers 📖 44🏛 4

✅ 0.58 ✨ 0.58 💥 0.00

## Mechanistic Overview...

mechanistic 0.78

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Disease-Associated Microglia

🧬 LPCAT3 🏥 alzheimers 📖 43🏛 3

✅ 0.58 ✨ 0.52 💥 0.00

## Mechanistic Overview...