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Each hypothesis is scored across 10 dimensions that determine scientific merit and therapeutic potential.
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green shows moderate-weight factors (safety, competition), and
yellow shows supporting dimensions (data availability, reproducibility).
Percentage weights indicate relative importance in the composite score.
5 citations5 with PMID5 mediumValidation: 0%5 supporting / 0 opposing
✓For(5)
5
No opposing evidence
(0)Against✗
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Evidence Matrix — sortable by strength/year, click Abstract to expand
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Abstract
Peak oxygen uptake measured during a perceptually-…
International Benchmark for Total Metabolic Tumor Volume Measurement in Baseline (18)F-FDG PET/CT of Lymphoma …MEDIUM▼
International Benchmark for Total Metabolic Tumor Volume Measurement in Baseline (18)F-FDG PET/CT of Lymphoma Patients: A Milestone Toward Clinical Implementation.
Test-retest variability of various quantitative measures to characterize tracer uptake and/or tracer uptake he…MEDIUM▼
Test-retest variability of various quantitative measures to characterize tracer uptake and/or tracer uptake heterogeneity in metastasized liver for patients with colorectal carcinoma.
Multi-persona evaluation:
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💬 Discussion
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No DepMap CRISPR Chronos data found for this gene.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
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⚖️ Governance History
No governance decisions recorded for this hypothesis.
Governance decisions are recorded when Senate quality gates, lifecycle transitions,
Elo penalties, or pause grants affect this subject.
IF experienced laboratory technicians perform manual uptake tests on cultured cells using standardized protocols, THEN the inter-rater reliability (Cohen's kappa) will exceed 0.85 compared to automated image analysis within 2 weeks of validation testing.
pendingconf: 0.65
Expected outcome: Manual uptake test will demonstrate high reproducibility across multiple trained operators with >85% agreement with automated quantification methods
Falsified by: Inter-rater reliability falls below 0.70 kappa coefficient, or manual measurements diverge from automated reference by >20% mean absolute error
Method: In vitro cell culture validation study comparing manual fluorescence microscopy uptake quantification by 5 trained technicians against automated high-content imaging analysis in HeLa or Caco-2 cells
IF the manual uptake test is applied to stratified cohorts of low versus high BMI subjects, THEN nutrient absorption coefficients will differ by >15% between groups within 4 weeks of cohort recruitment.
pendingconf: 0.55
Expected outcome: Stratified analysis will reveal statistically significant difference in uptake markers between BMI categories (low BMI <25 vs high BMI >30), with effect size Cohen's d > 0.5
Falsified by: No significant difference detected between BMI strata (p > 0.05), or difference in absorption coefficients is <10% between groups
Method: Prospective observational cohort study recruiting 60 adult participants stratified by BMI, measuring intestinal nutrient uptake via manual test with standardized oral challenge and serial plasma sampling over 6-hour period