Learning Path: Human Brain Cell Types

## Mechanistic Overview This hypothesis proposes using closed-loop transcranial focused ultrasound (tFUS) to selectively activate somatostatin-positive (SST) interneurons in entorhinal cortex layer II (EC-II) as an upstream intervention to restore hippocampal gamma oscillations in Alzheimer's disea...

## Mechanistic Overview GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance rests on the claim that modulating GRIN2B can redirect glymphatic protein clearance through effects on thalamocortical oscillatory dynamics. GluN2B subunits (encoded by GRIN2B) form extrasynaptic NMDA recep...

This hypothesis proposes that targeted modulation of microglial synaptic pruning activity can restore optimal functional connectivity patterns in diseased neural networks. Microglia express complement receptor 3 (CR3) and fractalkine receptor (CX3CR1) which mediate activity-dependent synaptic elimin...

Consensus: TREM2 signaling enables protective microglial responses to amyloid pathology based on human genetics showing loss-of-function variants increase AD risk (OR ~2-4); Microglial state transitions are ther | Dissent: Whether TREM2→TYROBP→APOE axis represents a pathogenic driver of irreversible inflammation (Theorist

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Science (New York, N.Y.) (2002) — cited 0×

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