Learning Path: Neuropsychiatry

## Mechanistic Overview This hypothesis proposes using closed-loop transcranial focused ultrasound (tFUS) to selectively activate somatostatin-positive (SST) interneurons in entorhinal cortex layer II (EC-II) as an upstream intervention to restore hippocampal gamma oscillations in Alzheimer's disea...

## Mechanistic Overview GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance rests on the claim that modulating GRIN2B can redirect glymphatic protein clearance through effects on thalamocortical oscillatory dynamics. GluN2B subunits (encoded by GRIN2B) form extrasynaptic NMDA recep...

## Mechanistic Overview TREM2 Signaling Bifurcation with Independent TYROBP-Independent Homeostatic Maintenance starts from the claim that modulating TREM2 within the disease context of neuroinflammation can redirect a disease-relevant process. The original description reads: "Background and Rationa...

Consensus: TREM2 signaling enables protective microglial responses to amyloid pathology based on human genetics showing loss-of-function variants increase AD risk (OR ~2-4); Microglial state transitions are ther | Dissent: Whether TREM2→TYROBP→APOE axis represents a pathogenic driver of irreversible inflammation (Theorist

Complete to continue

Science (New York, N.Y.) (2002) — cited 0×

Test your understanding of this learning path.