Genetic deletion of trpa1 receptor attenuates amyloid beta- 1-42 (aβ1-42)-induced neurotoxicity in the mouse basal forebrain in vivo.

Amyloid β 1-42 peptide (Aβ1-42) accumulates in Alzheimer's disease (AD) that is toxic to the basal forebrain cholinergic (BFC) neurons in substantia innominata-nucleus basalis magnocellularis complex (SI-NBM). Transient Receptor Potential Ankyrin1 (TRPA1) receptor is present in murine brain, however