Celastrol treatment attenuates the inflammatory response in Alzheimer's disease model mice.

OBJECTIVE: Alzheimer's disease (AD) is the most common neurodegenerative disease. Unfortunately, current effective therapeutics for AD are limited, and thus, the discovery of novel anti-AD agents is urgently needed. Celastrol, a plant-derived triterpene, has both antioxidant and anti-inflammatory activities. METHODS AND RESULTS: Here, we found that celastrol treatment promoted microglial M2 polarization and inhibited inflammatory factor expression in both CONCLUSION: Taken together, the results indicate that celastrol treatment attenuated the inflammatory response in AD mice by promoting microglial M2 polarization via the TLR4/NFκB pathway.