METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of tubular epithelial cells.

In response to tubular cell injury, the injured tubular cells undergoing apoptosis initiate the progression of renal fibrosis by releasing profibrotic factors and mediating intercellular communications. However, the regulatory mechanisms underlying tubular cell apoptosis remain elusive. In this study, we found that METTL3, the core methyltransferase of RNA N