GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression.

The critical role of group 2 innate lymphoid cells (ILC2s) in host defense and mucosal inflammation has been well established, yet the mechanisms underlying ILC2 survival and death remain unknown. Here, we report that ILC2s are vulnerable to ferroptosis, as evidenced by an abundance of ferroptosis signature genes and the accumulation of lipid peroxidation in ILC2s. Ablation of glutathione peroxidase 4 (GPX4) in ILC2s (Il5