Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and Therapeutic Frontiers.

Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation, critically contributes to cerebral ischemia/reperfusion (I/R) injury. In ischemic stroke, neuronal ferroptosis arises from iron overload and antioxidant system failure. Excessive Fe