Differential genome-wide association analysis of schizophrenia and post-traumatic stress disorder identifies opposing effects at the MAPT/CRHR1 locus.

BACKGROUND: Schizophrenia (SCZ) and post-traumatic stress disorder (PTSD) are severe psychiatric conditions with overlapping yet distinct symptomatology and pathophysiology. METHODS: We conducted a differential genome-wide association study (GWAS) to directly compare the genetic architectures of SCZ and PTSD using publicly available GWAS summary statistics from the Psychiatric Genomics Consortium (PGC). RESULTS: We identified four independent loci reaching genome-wide significance (P < 5 × 10 CONCLUSION: These findings provide evidence for distinct and opposing genetic contributions to SCZ and PTSD. The identification of the