Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates the MAPT locus on chromosome 17.

STUDY OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. Among the latter, sleep disturbances are particularly common and include insomnia, obstructive sleep apnea (OSA), and excessive daytime sleepiness. Here, we investigated the shared genetic architecture between PD and sleep-related traits to uncover biological pathways that underpin this relationship. METHODS: We analyzed genome-wide association study (GWAS) summary statistics for PD (~37.7 K cases, ~18.6 K proxy cases, ~1.4 M controls) and eight self-reported sleep-related traits (each with RESULTS: We observed a genome-wide genetic correlation between PD and daytime dozing ( CONCLUSIONS: These findings suggest that the