Association Between ACE (I/D) Polymorphism and Essential Hypertension (EH): An Updated Systematic Review and Meta-Analysis.

BACKGROUND: Essential hypertension (EH) refers to elevated arterial blood pressure with unknown etiology, which becomes more prevalent with age. Although the D allele of the METHODS: Case-control and cohort studies published in the last 20 years were reviewed from the main databases (PubMed, Scopus and Embase) using specific inclusion and exclusion criteria. Genotype data were used in meta-analyses using different genetic models. RESULTS: Twenty-two studies with 7690 participants (3886 cases and 3804 controls) were included. Significant associations were observed between the CONCLUSIONS: The findings support a significant association between the