PHF2 regulates grip strength via demethylation at the promoter region of the Mef2c.

Epigenetic modifications, including DNA methylation and histone modifications, play crucial roles in gene expression. Although histone H3 lysine-9 methylation (H3K9me) is a highly conserved repressive mark in heterochromatin regions, its specific function in skeletal muscle remains unclear. Here we demonstrate that PHF2, an H3K9me2 demethylase, is essential for skeletal muscle function, particularly in fast-twitch muscle fibers. Skeletal muscle-specific