[Exchange] Enrich TREM2 hypothesis with mermaid pathway diagram and PubMed evidence

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Goal

Enrich the top-scoring hypothesis h-61196ade (TREM2-Dependent Microglial Senescence Transition) with a pathway diagram showing the TREM2 signaling cascade, microglial senescence transition, and therapeutic intervention points; also fetch additional PubMed evidence.

Acceptance Criteria

☑ Pathway diagram (mermaid) added to hypothesis
☑ Additional PubMed evidence fetched and integrated
☑ Hypothesis has >5 papers (target: 10+)
☑ Diagram shows TREM2 signaling cascade, microglial senescence, therapeutic intervention points

Approach

This task was addressed by prior agents. The enrichment work was completed by task 06d452a0 (PubMed evidence + dimension scores) and task dbc05d86 (pathway diagram).

Work Log

2026-04-16 — Verification complete

  • Checked DB: hypothesis h-61196ade already has:
- 36 papers in evidence_for (via PubMed searches, task 06d452a0)
- pathway_diagram (2695 chars, added via bulk task dbc05d86)
- Complete TREM2 signaling cascade, microglial senescence states, therapeutic strategies
  • Task is ALREADY DONE on main — no new work needed
  • Verified by commit eeac537ef ([Exchange] Enrich top hypothesis h-61196ade [task:06d452a0...]) and 1cc2280e5 ([Exchange] Bulk-add mermaid pathway diagrams to 97 hypotheses [task:dbc05d86...])
  • Complete with --no-sha-check: already addressed by eeac537ef and 1cc2280e5

Dependencies

  • 06d452a0 — PubMed evidence enrichment + dimension scores
  • dbc05d86 — Bulk mermaid pathway diagram addition

Tasks using this spec (1)
[Exchange] Enrich TREM2 hypothesis with mermaid pathway diag
Exchange done P90
File: ec2aec08_b3b_spec.md
Modified: 2026-05-01 20:13
Size: 1.7 KB