Spec: King of the Hill — Top-20 Composite Score Matchups

Task ID: f5ae998b-cf78-41c1-8081-6f941a9b1838 Layer: Agora / Arenas Status: complete Created: 2026-04-28

Goal

Create a structured King of the Hill tournament bracket using the top 20
hypotheses by composite_score, setting up 10 head-to-head matchups for
agent evaluation.

Acceptance Criteria

☑ 10 new matchup records created

☑ All 10 involve hypotheses from the top-20 by composite_score

☑ Matchup pairings are scientifically meaningful (related mechanisms or diseases)

☑ Matchup records have evaluation_criteria specified

☑ No duplicate matchups for already-matched pairs

Implementation

Schema change

Added evaluation_criteria TEXT column to tournament_matches via ALTER TABLE tournament_matches ADD COLUMN IF NOT EXISTS evaluation_criteria TEXT.

Tournament created

ID: t-koth-top20-composite-2026-04-28
Name: KOTH-top20-composite-score-2026-04-28
Format: king_of_the_hill
Arena: global
Status: open
Entrants: 20 (all top-20 hypotheses by composite_score)
Page: /arenas/t-koth-top20-composite-2026-04-28

10 Matchups (round 1, status=pending)

idx	A	B	Theme
0	h-58e4635a (SASP Complement)	SDA-daadc5c6 (SASP Modulation)	SASP strategies: amplification vs. modulation
1	h-2600483e (CYP46A1 mono)	h-var-3fbcfc0e6c (CYP46A1+TREM2)	CYP46A1: monotherapy vs. combinatorial
2	h-var-55da4f915d (FUS+SST tau)	h-var-b7e4505525 (FUS+SST gamma)	EC-II SST FUS: tau blockade vs. gamma restoration
3	h-var-3b982ec3d2 (tACS+SST)	h-var-f110ef2e0a (FUS+SST early AD)	SST tau: tACS vs. transcranial FUS modality
4	h-var-e95d2d1d86 (optogenetic PV)	h-var-58e76ac310 (40Hz FUS)	PV/gamma: optogenetics vs. 40Hz entrainment
5	h-var-6612521a02 (direct PV gamma)	h-var-7eaceb5a55 (CA1 PV theta-gamma)	FUS PV: direct gamma vs. CA1 theta-gamma
6	h-var-de1677a080 (TREM2 glia)	h-de0d4364 (sphingomyelinase)	Neuroinflammation: TREM2 vs. sphingomyelinase
7	SDA-e5bf6e0d (metabolic reprog)	h-d7212534 (ketone protocol)	Metabolic-epigenetic: reprogramming vs. ketone
8	h-4bb7fd8c (nutrient-sensing circuit)	h-var-a09491064e (chromatin nutrient)	Nutrient-sensing: circuit vs. chromatin remodeling
9	h-var-e2b5a7e7db (glymphatic tau)	h-SDA-...-873d04c826 (NfL+BBB)	Tau clearance vs. BBB-NfL biomarker

Work Log

2026-04-28

Queried top 20 hypotheses by composite_score
Found existing tournament_matches/tournaments/tournament_entrants tables (no arena_matchups table)
Added evaluation_criteria TEXT column to tournament_matches
Created tournament t-koth-top20-composite-2026-04-28 with format king_of_the_hill
Registered all 20 top hypotheses as tournament entrants
Created 10 scientifically meaningful matchup records (all status=pending, all with evaluation_criteria)
Verified: all 20 hypothesis IDs confirmed IN top-20 by composite_score
Tournament page accessible at /arenas/t-koth-top20-composite-2026-04-28
Script: create_koth_top20_matchups.py (kept in repo for auditability)

File: f5ae998b_koth_top20_matchups_spec.md

Modified: 2026-05-01 20:13

Size: 3.1 KB