[Exchange] Enrich top hypotheses #4-#10 with pathway diagrams and clinical trials
Task ID
f9b8996d-a553-43c4-8419-06400012800a
Goal
Add pathway mermaid diagrams and clinical trial JSON data to hypotheses #4-#10 (by composite_score) that are missing this enrichment.
Current State
- Hypotheses #1-3 and #5-#10 already have pathway_diagram and clinical_trials populated
- Hypothesis #4 (CYP46A1 Overexpression Gene Therapy, h-2600483e) is missing both fields
- All other hypotheses in the top 10 are already enriched
Implementation
Created enrich_top_hypotheses.py script with:
- CYP46A1 pathway diagram showing cholesterol metabolism → lipid raft remodeling → Aβ reduction pathway
- 4 relevant clinical trials (AAV-CYP46A1 gene therapy, efavirenz repurposing, 24-OHC biomarker study, pharmacogenomics)
Script has retry logic for DB lock handlingWork Log
- 2026-04-02 07:05 — Started. Analyzed all top 10 hypotheses. Only #4 (CYP46A1, h-2600483e) missing enrichment.
- 2026-04-02 07:10 — Created enrichment script. DB currently corrupted (disk I/O error), script committed for later application.
- 2026-04-15 19:45 PT — Resumed task. Found DB no longer corrupted. Current top 10 had shifted: hypothesis #4 is now
hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-1 (Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible) with pathway already present but missing clinical trials. The original CYP46A1 hypothesis (h-2600483e) had been enriched via previous work. Added 4 clinical trials relevant to Aβ/cholinergic pathway: NCT06871839 (lecanemab synaptic plasticity), NCT05592678 (donepezil δ dementia), NCT05801380 (AChE inhibitor efficacy), NCT06639282 (siponimod repurposing). Verified all top 10 hypotheses now have both pathway and clinical_trials populated. API returns 200 for hypothesis page.