SIRT1

NAD-dependent protein deacetylase sirtuin-1

Score: 0.627 Price: $0.56 High Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 SIRT1 — PDB 4KXQ Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

High

Score: 0.80

Clinical Stage

Phase II

Target Class

Epigenetic Regulator

Safety

0.73

Druggability Analysis

Drug Development0.30

Structural Tractability0.70

Target Class0.70

Safety Profile0.73

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (3 compounds)

Therapeutic Areas:

Neurodegeneration Aging Metabolic Disease

Mechanism: SIRT1 activation via NAD+ precursors or allosteric activators deacetylates tau (reducing aggregation), enhances mitophagy, and restores circadian gene expression

Drug Pipeline (3 compounds)

Known Drugs:

NMN (Clinical Trials)

Resveratrol (Clinical Trials)

SRT2104 (Phase 2)

Structural Data:

PDB (5) ✓AlphaFold ✓Cryo-EM —

4KXQ 5BTR 4IG9 4ZZH 5BTR

UniProt: Q96EB6

🧬 3D Protein Structure

🧬 SIRT1 — PDB 4KXQ Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure

PDB: Open in RCSB AlphaFold model

Interactive 3D viewer powered by RCSB PDB / Mol*. Use mouse to rotate, scroll to zoom.

Linked Hypotheses (3)

Nutrient-Sensing Epigenetic Circuit Reactivation0.670

SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence0.600

Astrocyte Metabolic Memory Reprogramming0.478

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

associated with (19)

SIRT1 → LC3

SIRT1 → SNAP29

SIRT1 → RB1

SIRT1 → KAT2B

SIRT1 → KAT5

...and 14 more

regulates (1)

SIRT1 → CELLULAR_METABOLISM

Debate History (0)

No debates yet