Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SIRT1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 1385 entities in the SciDEX knowledge graph.
| Gene Symbol | SIRT1 |
| Chromosome | 10q21.3<br> |
| Target Class | Epigenetic Regulator |
| Function | SIRT1 uses NAD+ as a cofactor, linking its activity to cellular energy status and metabolic health. |
| Mechanism of Action | SIRT1 activation via NAD+ precursors or allosteric activators deacetylates tau (reducing aggregation), enhances mitophagy, and restores circadian gene expression |
| Druggability | High (0.80) |
| Clinical Stage | Phase II |
| Pathways | Akt, Ampk Signaling, Angiogenesis, Apoptosis, Autophagy |
| UniProt ID | Q96EB6 |
| NCBI Gene ID | 23411 |
| Ensembl ID | ENSG00000096717 |
| GeneCards | SIRT1 |
| Human Protein Atlas | SIRT1 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, APOPTOSIS, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, METFORMIN, Resveratrol, polyphenols, curcumin, resveratrol |
| Interactions | DNM1L, PRKAA1, KDM6B, LC3, RPTOR, PRKAA2 |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Nutrient-Sensing Epigenetic Circuit Reactivation SIRT1-Mediated Reversal of TREM2-Dependent Microgl Astrocyte Metabolic Memory Reprogramming |
| KG Connections | 2938 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SIRT1["SIRT1"] -->|"promotes"| AUTOPHAGY["AUTOPHAGY"]
SIRT1["SIRT1"] -.->|"inhibits"| OXIDATIVE_STRESS["OXIDATIVE_STRESS"]
SIRT1["SIRT1"] -->|"activates"| autophagy["autophagy"]
SIRT1["SIRT1"] -->|"promotes"| autophagy_1["autophagy"]
SIRT1["SIRT1"] -->|"associated"| Tumor["Tumor"]
SIRT1["SIRT1"] -->|"associated"| Parkinson["Parkinson"]
QBA["QBA"] -->|"activates"| SIRT1["SIRT1"]
LACTATE["LACTATE"] -->|"activates"| SIRT1["SIRT1"]
AMPK["AMPK"] -->|"activates"| SIRT1["SIRT1"]
METFORMIN["METFORMIN"] -->|"activates"| SIRT1["SIRT1"]
style SIRT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MTOR | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| Aging | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Obesity | activates | disease | 1.00 |
| Senescence | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| P53 | activates | gene | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Cardiac | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Longevity | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| AGING | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | activates | pathway | 1.00 |
| PARKIN | activates | gene | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Mitochondrial Function | activates | pathway | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| Cardiovascular | therapeutic_target | disease | 0.95 |
| Senescence | therapeutic_target | disease | 0.95 |
| Tumor | inhibits | disease | 0.95 |
| Aging | associated_with | disease | 0.95 |
| Diabetes | activates | disease | 0.95 |
| Inflammation | associated_with | disease | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| NAD | regulates | gene | 1.00 |
| NAD | associated_with | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| NAD | activates | gene | 1.00 |
| AMPK | activates | protein | 0.98 |
| Metformin | upregulates | drug | 0.95 |
| Melatonin | upregulates | drug | 0.95 |
| NS5 | interacts_with | protein | 0.95 |
| SRT2104 | activates | drug | 0.95 |
| Srt2104 | activates | drug | 0.95 |
| AMPK | upstream_of | protein | 0.95 |
| CHK1 | interacts_with | protein | 0.95 |
| TBEV NS5 | interacts_with | protein | 0.93 |
| Qigui Jiangzhi Formula | upregulates | drug | 0.90 |
| AUTOPHAGY | activates | gene | 0.90 |
| NF-KB | associated_with | protein | 0.90 |
| NF-kB | inhibits | protein | 0.90 |
| resveratrol | activates | drug | 0.90 |
| NAD+ | activates | protein | 0.90 |
| CHK1 | phosphorylates | protein | 0.90 |
| h-4bb7fd8c | targets_gene | hypothesis | 0.90 |
| h-827a821b | targets_gene | hypothesis | 0.90 |
| h-7c3c0f40 | targets_gene | hypothesis | 0.90 |
| h-c69709f5 | targets_gene | hypothesis | 0.90 |
| h-var-b7de826706 | targets_gene | hypothesis | 0.90 |
| SIRT3 | expressed_in | gene | 0.90 |
| PINK1 | activates | gene | 0.90 |
| SIRT3 | activates | gene | 0.90 |
| PARKINSON'S DISEASE | activates | gene | 0.90 |
| APOPTOSIS | therapeutic_target | gene | 0.90 |
| NAMPT | activates | protein | 0.89 |
| SMURF2 | degrades | protein | 0.88 |
| Oleic Acid | downregulates | compound | 0.85 |
| tmTNF-α | upregulates | protein | 0.85 |
| nicotinamide | targets | drug | 0.85 |
| Melatonin | activates | drug | 0.85 |
| Resveratrol | activates | drug | 0.85 |
| NAMPT/NAD+ pathway | upstream_of | pathway | 0.85 |
| NPFF | activates | protein | 0.85 |
| time-restricted feeding | activates | process | 0.85 |
| intermittent fasting | activates | drug | 0.85 |
| NF-κB | interacts_with | pathway | 0.85 |
| APOPTOSIS | associated_with | gene | 0.82 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.82 |
| h-4bb7fd8c | targets | hypothesis | 0.80 |
| Morusin | activates | chemical | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Nutrient-Sensing Epigenetic Circuit Reactivation | 0.670 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc | 0.600 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging | 0.587 | neurodegeneration | Gene expression changes in aging mouse b |
| SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R | 0.498 | neuropharmacology | What determines blood-brain barrier pene |
| Astrocyte Metabolic Memory Reprogramming | 0.478 | neurodegeneration | How do astrocyte-neuron metabolic intera |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.670
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.790
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008] | Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, | Journal of molecular cell biol | 2026 | 0 |
| Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438] | Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S | Current neuropharmacology | 2026 | 0 |
| Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033] | Jalouli M, Harrath AH, Al-Zharani M, Rah | Nutrients | 2026 | 0 |
| Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754] | Li W, Wang WH, Song Y, Li XJ, Li Y et al | Int J Mol Med | 2026 | 0 |
| Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709] | Achar PG, Krishna KL, C P K, Patil M, Pr | Neuroscience | 2026 | 0 |
| Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697] | Lagartos-Donate MJ, Escobar-Doncel B, Zh | Brain | 2026 | 0 |
| SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therape [PMID:41934491] | Alameen AAM, Al-Kuraishy HM, Al-Gareeb A | Neuromolecular Med | 2026 | 0 |
| Valsartan promotes neuroprotection in Parkinson's disease via epigenetic modulat [PMID:41936814] | Gowied HG, El-Mezayen NS, Afify EA | Life Sci | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |
| Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases. [PMID:41759326] | Shah A, Doshi G | Ageing research reviews | 2026 | 0 |
| Urolithin A Reverses Intranigral Rotenone-Generated Parkinsonism by Modulating D [PMID:41880654] | Devi A, Singh SB, Srivastava S, Dandekar | ACS chemical neuroscience | 2026 | 0 |
| Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can [PMID:41902653] | Merlo S, Lipari CLR, Patti A, Sortino MA | Phytotherapy research : PTR | 2026 | 0 |
| Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic net [PMID:41692938] | Ungvari Z, Menyhárt O, Ocana A, Lehoczki | GeroScience | 2026 | 0 |
| All the Way: A Decade of SIRT1 in Breast Cancer. [PMID:41898317] | Pratelli G, Montalbano M, Affranchi F, O | Biomedicines | 2026 | 0 |
| Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic [PMID:41894075] | Kuwar OK, Tejpal S, Sharma V, Sharma A, | Molecular biology reports | 2026 | 0 |
| Uncovering the metabolic-epigenetic links between gene expression and stroke: in [PMID:41877258] | Kan J, Hong Y, Min R, Zhang B, Wang H | Neurological research and prac | 2026 | 0 |
| Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging. [PMID:41863647] | Ramamonjiharisoa MBM, Liu S | Amino acids | 2026 | 0 |
| Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential [PMID:41869013] | Chen W, Huang S, He L, Zhou X, Li R, Wan | Frontiers in cell and developm | 2026 | 0 |
| Unraveling Network Pharmacology-Based Therapeutics of Anthranilate Sulfonamides [PMID:41714304] | Ruankham W, Prachayasittikul V, Pingaew | Journal of neurochemistry | 2026 | 0 |
| Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerati [PMID:41868184] | Liu Z, Zhang H, Wan B, Yin S, Yue R | Drug design, development and t | 2026 | 0 |