protein

LC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3286Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

Page for LC3 (Microtubule-Associated Protein 1 Light Chain 3)

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🔬 Protein Info

Gene Symbol	LC3
Full Name	MAP1LC3A
Aliases	Microtubule-Associated Protein 1 Light Chain 3
Protein Type	Transcription Factor
Function	LC3 is essential for autophagosome formation and function
Molecular Weight	17 kDa
Pathways	Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
NCBI Gene ID	Search NCBI
GeneCards	LC3
Human Protein Atlas	LC3
Associated Diseases	AD, ALI, ALS, AMI, ARM, Aging
Known Drugs/Compounds	RAPAMYCIN, ATTECs, licorice, nicotinamide, statins, dimethyl fumarate
Interactions	MTOR, ABCG1, SQSTM1, ABCA1, APOE, LOX
KG Connections	3286 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LC3["LC3"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LC3["LC3"] <-->|"interacts with"| Als["Als"]
    LC3["LC3"] <-->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    LC3["LC3"] <-->|"interacts with"| Dementia["Dementia"]
    LC3["LC3"] <-->|"interacts with"| Cardiovascular["Cardiovascular"]
    LC3["LC3"] <-->|"interacts with"| Alzheimer["Alzheimer"]
    LC3["LC3"] <-->|"interacts with"| Parkinson["Parkinson"]
    LC3["LC3"] <-->|"interacts with"| Ms["Ms"]
    LC3["LC3"] <-->|"interacts with"| Cancer["Cancer"]
    LC3["LC3"] <-->|"interacts with"| Fibrosis["Fibrosis"]
    LC3["LC3"] ---|"associated with"| Glioblastoma["Glioblastoma"]
    LC3["LC3"] ---|"associated with"| Tumor["Tumor"]
    style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (1864)

Target	Relation	Type	Str
SQSTM1	activates	gene	1.00
MTOR	activates	gene	1.00
P62	activates	gene	1.00
AKT	activates	gene	1.00
ULK1	activates	gene	1.00
Als	interacts_with	disease	1.00
Autophagy	interacts_with	pathway	1.00
Mtor	inhibits	pathway	1.00
Tumor	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Mtor	associated_with	pathway	1.00
Als	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
Autophagy	activates	pathway	1.00
Mtor	activates	pathway	1.00
Alzheimer	activates	disease	1.00
Cancer	associated_with	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
Als	regulates	disease	1.00
Autophagy	regulates	pathway	1.00
Apoptosis	activates	pathway	1.00
Inflammation	activates	disease	1.00
Mitophagy	activates	pathway	1.00
Phagocytosis	associated_with	pathway	1.00
Als	inhibits	disease	1.00
Autophagy	inhibits	pathway	1.00
Tumor	inhibits	disease	1.00
Oxidative Stress	activates	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Aging	activates	disease	1.00
Cancer	inhibits	disease	1.00
LC3B	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
CANCER	activates	gene	1.00
MITOCHONDRIA	interacts_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
PHAGOCYTOSIS	associated_with	gene	1.00
Pi3K/Akt	activates	pathway	1.00
MITOCHONDRIA	activates	gene	1.00
Infection	activates	disease	1.00
AKT	inhibits	gene	1.00
Mitophagy	interacts_with	pathway	1.00
Phagocytosis	activates	pathway	1.00
AUTOPHAGY	interacts_with	gene	1.00
DNA	activates	gene	1.00
GENES	activates	gene	1.00

Incoming (1422)

Source	Relation	Type	Str
P62	interacts_with	gene	1.00
ATG7	activates	gene	1.00
PI3K	activates	gene	1.00
ATG5	activates	gene	1.00
P62	activates	gene	1.00
BECLIN1	activates	gene	1.00
MAP1LC3	activates	gene	1.00
ATG	interacts_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
MITOPHAGY	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
AUTOPHAGY	inhibits	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
GFP	associated_with	gene	1.00
ROS	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
PINK1	activates	gene	1.00
SQSTM1	activates	gene	1.00
P62	regulates	gene	1.00
TNF	activates	gene	1.00
ATG5	associated_with	gene	1.00
BAX	activates	gene	1.00
MAP1LC3	associated_with	gene	1.00
CANCER	activates	gene	1.00
MITOPHAGY	interacts_with	gene	1.00
ATG8	interacts_with	gene	1.00
BECN1	activates	gene	0.98
APOPTOSIS	associated_with	gene	0.98
ALZHEIMER'S DISEASE	associated_with	disease	0.98
TGM2	binds_to	entity	0.95
TFAM LIR motif	binds_to	protein_domain	0.95
L1CAM	interacts_with	protein	0.95
CD274	interacts_with	protein	0.95
TDP43	regulates	entity	0.92
TFEB	regulates	protein	0.90
paeoniflorin	contributes_to	drug	0.90
ginseng root extract	contributes_to	drug	0.90
SQSTM1	binds	gene	0.90
TGM2	binds	protein	0.90
AKT	associated_with	gene	0.90
BECN1	upregulates	entity	0.90
p62/SQSTM1	binds	protein	0.90
P2RY12	inhibits	entity	0.90
oleanonic acid	upregulates	drug	0.90
AMPK	activates	gene	0.90
TRIAD3A	binds	gene	0.90
TRIAD3A	regulates	gene	0.90
AUTOPHAGY	regulates	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LC3

Understanding Entity Pages

Summary

Wiki Pages (21)

MAP1LC3A Gene

cbs-psp-daily-action-plan

Mitochondrial Quality Control

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Sulforaphane and Nrf2 Activation for Neuroprotection

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Epigenetic Alterations in Alzheimer's Disease

vitamin-d-therapy-neurodegeneration

Gene-Mechanism-Therapy Causal Chains

proteasome-ubiquitin-system-dysfunction-parkinsons

Neuroinflammation-Mitochondria Crosstalk Pathway

mitophagy-defect

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Genistein for Mild Cognitive Impairment (NCT07385937)

rapamycin-tauopathy

FOXO1 Protein

mitochondrial-dynamics-dysfunction-parkinsons