gene

SNAP29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

725Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for SNAP29 — Synaptosomal-Associated Protein 29

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🧬 Gene Info

Gene Symbol	SNAP29
Full Name	Synaptosomal-Associated Protein 29
Function	is a member of the SNAP25 family of SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins[@snap2018][@snap2020].
Subcellular Localization	</th><td>Cytoplasm, Plasma Membrane, Endosomes</td></tr>
Molecular Weight	29 kDa
Pathways	NOTCH
GeneCards	SNAP29
Human Protein Atlas	SNAP29
Associated Diseases	ALS, Aging, Ftd, Glioblastoma, Melanoma
Known Drugs/Compounds	rapamycin
Interactions	VAMP8, PI3K, STX17, DRAM1, STUB1, AKT
KG Connections	725 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 2796 words

→

Pathway Diagram

graph TD
    SNAP29["SNAP29"] -->|"Associated With"| Glioblastoma["Glioblastoma"]
    SNAP29["SNAP29"] -->|"Associated With"| Tumor["Tumor"]
    SNAP29["SNAP29"] -->|"Associated With"| Parkinson["Parkinson"]
    SNAP29["SNAP29"] -->|"Associated With"| Ms["Ms"]
    SNAP29["SNAP29"] -->|"Associated With"| Als["Als"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Neurodegeneration["Neurodegeneration"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Aging["Aging"]
    SNAP29["SNAP29"] -->|"Activates"| Carcinoma["Carcinoma"]
    VAMP8["VAMP8"] -->|"Associated With"| SNAP29["SNAP29"]
    LAMP2["LAMP2"] -->|"Associated With"| SNAP29["SNAP29"]
    GBM["GBM"] -->|"Associated With"| SNAP29["SNAP29"]
    LC3["LC3"] -->|"Associated With"| SNAP29["SNAP29"]
    EPG5["EPG5"] -->|"Associated With"| SNAP29["SNAP29"]
    style SNAP29 fill:#8d4900,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style VAMP8 fill:#8d4900,color:#e0e0e0
    style LAMP2 fill:#8d4900,color:#e0e0e0
    style GBM fill:#8d4900,color:#e0e0e0
    style LC3 fill:#8d4900,color:#e0e0e0
    style EPG5 fill:#8d4900,color:#e0e0e0

Outgoing (423)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
Autophagosome-Lysosome Fusion	involved_in	process	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy	involved_in	process	0.90
SNARE Complex Formation	inhibits	process	0.88
ubiquitin-proteasome	participates_in	pathway	0.80
Tumor	associated_with	disease	0.75
STX17	associated_with	gene	0.70
ULK1	regulates	gene	0.70
STX17	implicated_in	gene	0.70
Autophagy	activates	pathway	0.70
LYSOSOME	regulates	gene	0.70
Glioblastoma	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Aging	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Neuropathy	associated_with	disease	0.65
Hepatitis	regulates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Schizophrenia	associated_with	disease	0.65
Schizophrenia	regulates	disease	0.65
Autism	regulates	disease	0.65
ALS	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Infection	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
Ftd	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Aging	encodes	disease	0.65

Incoming (302)

Source	Relation	Type	Str
SIDE	phosphorylates	protein	0.85
VAMP8	associated_with	gene	0.70
LC3	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
P62	associated_with	gene	0.70
RB1	activates	gene	0.70
MTOR	regulates	gene	0.70
RB1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
ATG	activates	gene	0.70
RUBCNL	activates	gene	0.70
rapamycin	targets	drug	0.70
ATG	regulates	gene	0.70
LAMP2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
STX17	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB2A	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
STX17	regulates	gene	0.60
RAB5	therapeutic_target	gene	0.60
SDC1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
RB1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SNAP29

Understanding Entity Pages

Summary

Wiki Pages (21)

SNAP29 — Synaptosomal-Associated Protein 29

Lysosomal Dysfunction in Neurodegeneration

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

Endolysosomal Trafficking Defects in Neurodegeneration

Synaptic Loss in Alzheimer's Disease Pathway

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

autophagy-lysosomal-ad

VAMP8 — Vesicle Associated Membrane Protein 8

TUFM Gene

STX17 Gene

CBS Autophagy-Lysosomal Pathway Dysfunction

protein-trafficking-pathways

vps26

CREB Neurons

GCAT — Glycerol-3-Phosphate O-Acetyltransferase

VPS33B Gene

KAT8 Gene

STX17 Protein