gene

SNAP29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

709Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for SNAP29 — Synaptosomal-Associated Protein 29

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🧬 Gene Info

Gene Symbol	SNAP29
Full Name	Synaptosomal-Associated Protein 29
Function	is a member of the SNAP25 family of SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins[@snap2018][@snap2020].
Subcellular Localization	</th><td>Cytoplasm, Plasma Membrane, Endosomes</td></tr>
Molecular Weight	29 kDa
Pathways	NOTCH
GeneCards	SNAP29
Human Protein Atlas	SNAP29
Associated Diseases	Aging, Als, Ftd, Glioblastoma, Melanoma
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, ACTB, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	709 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SNAP29 — Synaptosomal-Associated Protein 29

gene · 992 words

→

SNAP29 Protein

protein · 611 words

→

Pathway Diagram

graph TD
    SNAP29["SNAP29"] -->|"Associated With"| Glioblastoma["Glioblastoma"]
    SNAP29["SNAP29"] -->|"Associated With"| Tumor["Tumor"]
    SNAP29["SNAP29"] -->|"Associated With"| Parkinson["Parkinson"]
    SNAP29["SNAP29"] -->|"Associated With"| Ms["Ms"]
    SNAP29["SNAP29"] -->|"Associated With"| Als["Als"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Neurodegeneration["Neurodegeneration"]
    SNAP29["SNAP29"] -->|"Therapeutic Target"| Aging["Aging"]
    SNAP29["SNAP29"] -->|"Activates"| Carcinoma["Carcinoma"]
    VAMP8["VAMP8"] -->|"Associated With"| SNAP29["SNAP29"]
    LAMP2["LAMP2"] -->|"Associated With"| SNAP29["SNAP29"]
    GBM["GBM"] -->|"Associated With"| SNAP29["SNAP29"]
    LC3["LC3"] -->|"Associated With"| SNAP29["SNAP29"]
    EPG5["EPG5"] -->|"Associated With"| SNAP29["SNAP29"]
    style SNAP29 fill:#8d4900,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style VAMP8 fill:#8d4900,color:#e0e0e0
    style LAMP2 fill:#8d4900,color:#e0e0e0
    style GBM fill:#8d4900,color:#e0e0e0
    style LC3 fill:#8d4900,color:#e0e0e0
    style EPG5 fill:#8d4900,color:#e0e0e0

Outgoing (412)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
Autophagosome-Lysosome Fusion	involved_in	process	0.90
Autophagy	associated_with	process	0.90
autophagy pathway	participates_in	pathway	0.90
SNARE Complex Formation	inhibits	process	0.88
ubiquitin-proteasome	participates_in	pathway	0.80
Tumor	associated_with	disease	0.75
STX17	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
LYSOSOME	regulates	gene	0.70
ULK1	regulates	gene	0.70
Cancer	regulates	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	encodes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Melanoma	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neurodegeneration	encodes	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	encodes	disease	0.65
Infection	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Aging	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuropathy	associated_with	disease	0.65
Hepatitis	regulates	disease	0.65

Incoming (297)

Source	Relation	Type	Str
SIDE	phosphorylates	protein	0.85
VAMP8	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
P62	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
rapamycin	targets	drug	0.70
ATG	activates	gene	0.70
RUBCNL	activates	gene	0.70
LC3	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
RB1CC1	regulates	gene	0.70
MTOR	regulates	gene	0.70
RB1	regulates	gene	0.70
RB1	activates	gene	0.70
ATG	regulates	gene	0.70
TDP-43 Aggregation	associated_with	phenotype	0.70
AND	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
AMPK	activates	entity	0.60
AMPK	regulates	gene	0.60
CREB	regulates	gene	0.60
GABA	regulates	gene	0.60
RAS	regulates	gene	0.60
AND	activates	gene	0.60
DNA	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
ROS	associated_with	gene	0.60
RAB7	regulates	gene	0.60
GSN	expressed_in	gene	0.60
SNAP25	associated_with	gene	0.60
PPP1R1B	expressed_in	gene	0.60
BNIP3	inhibits	gene	0.60
NRXN1	associated_with	gene	0.60
CHRNA7	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
VPS26	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
P62	activates	gene	0.60
GAPDH	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
FUS	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

neurodegeneration | 2026-04-08 | 4 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While ALS-causing mutations impair autophagy factors, the neuron-specific effect

closed · Rounds: 4 · Score: 0.81 · 2026-04-21

Related Research

Hypotheses and analyses mentioning SNAP29 in their description or question text

No additional research found