Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RB1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, ALS. Connected to 840 entities in the SciDEX knowledge graph.
| Gene Symbol | RB1 |
| Full Name | Retinoblastoma 1 |
| Chromosome | 13q14.2 |
| Function | is a critical tumor suppressor gene with important functions in the nervous system. |
| Pathways | Akt, Apoptosis, Autophagy, Dna Methylation, E2F pathway |
| UniProt ID | P06400 |
| NCBI Gene ID | 5925 |
| Ensembl ID | ENSG00000139687 |
| OMIM | 180200 |
| GeneCards | RB1 |
| Human Protein Atlas | RB1 |
| Official Symbol | RB1 |
| Official Full Name | Retinoblastoma 1 |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | EIF2AK3, PRKN, BCL2L11, MUL1, BNIP3, DISC1 |
| KG Connections | 1584 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RB1["RB1"] -->|"interacts"| Dementia["Dementia"]
RB1["RB1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
RB1["RB1"] -->|"interacts"| Als["Als"]
RB1["RB1"] -->|"interacts"| Alzheimer["Alzheimer"]
RB1["RB1"] -->|"interacts"| Parkinson["Parkinson"]
RB1["RB1"] -->|"interacts"| Ms["Ms"]
CAT["CAT"] -->|"interacts"| RB1["RB1"]
OPTN["OPTN"] -->|"interacts"| RB1["RB1"]
DNM1L["DNM1L"] -->|"interacts"| RB1["RB1"]
CANX["CANX"] -->|"interacts"| RB1["RB1"]
style RB1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| retinoblastoma | causes | disease | 0.95 |
| small cell lung carcinoma | risk_factor_for | disease | 0.95 |
| cell cycle | regulates | pathway | 0.90 |
| ESCC | causes | disease | 0.90 |
| second cancer | contributes_to | disease | 0.80 |
| DNMT1 | regulates | gene | 0.80 |
| TERRA | regulates | gene | 0.80 |
| oxidative stress response | participates_in | pathway | 0.80 |
| ubiquitin-proteasome | participates_in | pathway | 0.80 |
| neural stem cells | activates | cell_type | 0.80 |
| neural stem cells | regulates | cell_type | 0.80 |
| RB1CC1 | associated_with | gene | 0.80 |
| LC3 | associated_with | gene | 0.80 |
| Autophagy | associated_with | pathway | 0.80 |
| AUTOPHAGY | associated_with | gene | 0.80 |
| Tumor | associated_with | disease | 0.75 |
| Parkinson | associated_with | disease | 0.75 |
| Als | associated_with | disease | 0.75 |
| Cancer | therapeutic_target | disease | 0.75 |
| Tumor | therapeutic_target | disease | 0.75 |
| Aging | therapeutic_target | disease | 0.75 |
| Tumor | inhibits | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| Hepatocellular Carcinoma | suppresses | disease | 0.72 |
| WIPI2 | associated_with | gene | 0.70 |
| NBR1 | associated_with | gene | 0.70 |
| MTOR | associated_with | gene | 0.70 |
| PIK3C3 | associated_with | gene | 0.70 |
| TP53 | associated_with | gene | 0.70 |
| PRKN | associated_with | gene | 0.70 |
| CALCOCO2 | associated_with | gene | 0.70 |
| E2F pathway | regulates | pathway | 0.70 |
| oxidative phosphorylation | regulates | process | 0.70 |
| GLUT1 inhibition sensitivity | biomarker_for | biomarker_for | 0.70 |
| GLUT1 inhibitor sensitivity | regulates | process | 0.70 |
| p21Cip1 | regulates | gene | 0.70 |
| p16INK4a | regulates | gene | 0.70 |
| Cyclin D1 | regulates | gene | 0.70 |
| Cyclin E1 | regulates | gene | 0.70 |
| Cyclin B1 | regulates | gene | 0.70 |
| UBIQUITIN | associated_with | gene | 0.70 |
| TFEB | associated_with | gene | 0.70 |
| GABARAP | associated_with | gene | 0.70 |
| STING1 | activates | gene | 0.70 |
| STING1 | regulates | gene | 0.70 |
| STX17 | activates | gene | 0.70 |
| STX17 | regulates | gene | 0.70 |
| RTN3 | activates | gene | 0.70 |
| SNAP29 | activates | gene | 0.70 |
| VAMP8 | activates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TP53 | coexpressed_with | gene | 0.85 |
| RB1CC1 | regulates | gene | 0.80 |
| NBR1 | activates | gene | 0.80 |
| NBR1 | regulates | gene | 0.80 |
| OPTN | regulates | gene | 0.80 |
| FIP200 | regulates | gene | 0.80 |
| ATG | regulates | gene | 0.80 |
| rapamycin | targets | drug | 0.80 |
| FGFR3 | interacts_with | gene | 0.70 |
| TP53 | activates | gene | 0.70 |
| CDK4 | interacts_with | protein | 0.70 |
| BECN1 | associated_with | gene | 0.70 |
| FIP200 | associated_with | gene | 0.70 |
| NDP52 | activates | gene | 0.70 |
| PRKN | activates | gene | 0.70 |
| JNK | regulates | gene | 0.70 |
| MAP1LC3B | regulates | gene | 0.70 |
| NDP52 | regulates | gene | 0.70 |
| PRKN | regulates | gene | 0.70 |
| PIK3C3 | activates | gene | 0.70 |
| PIK3C3 | regulates | gene | 0.70 |
| CALCOCO2 | activates | gene | 0.70 |
| DNM1L | activates | gene | 0.70 |
| EIF2AK3 | activates | gene | 0.70 |
| ERN1 | activates | gene | 0.70 |
| GABARAP | activates | gene | 0.70 |
| CALCOCO2 | regulates | gene | 0.70 |
| DDIT3 | regulates | gene | 0.70 |
| DNM1L | regulates | gene | 0.70 |
| EIF2AK3 | regulates | gene | 0.70 |
| ERN1 | regulates | gene | 0.70 |
| GABARAP | regulates | gene | 0.70 |
| P16 | regulates | protein | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| P53 | inhibits | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| AMPK | regulates | gene | 0.70 |
| DNA | regulates | gene | 0.70 |
| GABA | activates | gene | 0.70 |
| GABA | regulates | gene | 0.70 |
| NLR | activates | gene | 0.70 |
| NLR | regulates | gene | 0.70 |
| RAPAMYCIN | activates | drug | 0.65 |
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||