protein

RB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1596Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

RB1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, ALS. Connected to 840 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolRB1
Full NameRetinoblastoma 1
Chromosome13q14.2
Functionis a critical tumor suppressor gene with important functions in the nervous system.
PathwaysAkt, Apoptosis, Autophagy, Dna Methylation, E2F pathway
UniProt IDP06400
NCBI Gene ID5925
Ensembl IDENSG00000139687
OMIM180200
GeneCardsRB1
Human Protein AtlasRB1
Official SymbolRB1
Official Full NameRetinoblastoma 1
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/CompoundsRAPAMYCIN, rapamycin
InteractionsEIF2AK3, PRKN, BCL2L11, MUL1, BNIP3, DISC1
KG Connections1584 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RB1 — AlphaFold P06400 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RB1 — Retinoblastoma 1

gene · 873 words

Alzheimer's Disease

disease · 5265 words

Section 189: Advanced Autophagy-Endolysosomal Pathway Therapy in CBS/PSP

therapeutic · 3096 words

Astrocyte Senescence Pathway in Neurodegeneration

mechanism · 2947 words

Cyclin E2 (CCNE2) Protein

protein · 2832 words

CDK6 Protein

protein · 2710 words

Pathway Diagram

graph TD
    RB1["RB1"] -->|"interacts"| Dementia["Dementia"]
    RB1["RB1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    RB1["RB1"] -->|"interacts"| Als["Als"]
    RB1["RB1"] -->|"interacts"| Alzheimer["Alzheimer"]
    RB1["RB1"] -->|"interacts"| Parkinson["Parkinson"]
    RB1["RB1"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| RB1["RB1"]
    OPTN["OPTN"] -->|"interacts"| RB1["RB1"]
    DNM1L["DNM1L"] -->|"interacts"| RB1["RB1"]
    CANX["CANX"] -->|"interacts"| RB1["RB1"]
    style RB1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (809)

TargetRelationTypeStr
retinoblastomacausesdisease0.95
small cell lung carcinomarisk_factor_fordisease0.95
cell cycleregulatespathway0.90
ESCCcausesdisease0.90
second cancercontributes_todisease0.80

Incoming (787)

SourceRelationTypeStr
TP53coexpressed_withgene0.85
RB1CC1regulatesgene0.80
NBR1activatesgene0.80
NBR1regulatesgene0.80
OPTNregulatesgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found