gene

KAT2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

193Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

KAT2B is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Parkinson, Tumor. Connected to 90 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KAT2B
Full Name	Lysine Acetyltransferase 2B
Chromosome	3p24.3
Protein Type	Transferase
Function	KAT2B (also known as PCAF - p300/CBP-associated factor) encodes a histone acetyltransferase that plays a crucial role in transcriptional regulation through chromatin remodeling.
Primary Expression	various brain regions and cell types, where it contributes to synaptic transmission, gene regulation, and intracellular signaling cascades
Pathways	Autophagy
UniProt ID	[Q92830](https://www.uniprot.org/uniprot/Q92830)
Ensembl ID	ENSG00000114166
OMIM	602303
GeneCards	KAT2B
Human Protein Atlas	KAT2B
Associated Diseases	Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	LC3, RB1, PARKINSON, AMPK, MAP1LC3, Proteins
KG Connections	193 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KAT2B["KAT2B"]
    KAT2B -->|"implicated in"| neurodegeneration["neurodegeneration"]
    KAT2B ---|"associated"| Tumor["Tumor"]
    KAT2B ---|"associated"| Parkinson["Parkinson"]
    KAT2B ---|"associated"| KAT5["KAT5"]
    KAT2B ---|"associated"| WIPI2["WIPI2"]
    KAT2B ---|"associated"| BECN1["BECN1"]
    KAT2B ---|"associated"| HDAC6["HDAC6"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| KAT2B
    OPTN["OPTN"] ---|"associated"| KAT2B
    ULK1["ULK1"] ---|"associated"| KAT2B
    CALCOCO2["CALCOCO2"] ---|"associated"| KAT2B
    HSPA8["HSPA8"] ---|"associated"| KAT2B
    STX17["STX17"] ---|"associated"| KAT2B
    SQSTM1["SQSTM1"] ---|"associated"| KAT2B

Outgoing (105)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LC3	regulates	gene	0.60
ATG16L1	regulates	gene	0.60
HDAC3	regulates	gene	0.60
KAT5	activates	entity	0.60
KAT8	activates	entity	0.60
LAMP2A	activates	entity	0.60
MTOR	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
RB1CC1	activates	entity	0.60
RUBCN	activates	entity	0.60
SIRT1	activates	entity	0.60
SNAP29	activates	entity	0.60
SQSTM1	activates	entity	0.60
STX17	activates	entity	0.60

Incoming (88)

Source	Relation	Type	Str
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
TP53	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
HSPA8	activates	entity	0.60
KAT2A	activates	entity	0.60
CBP	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
P53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KAT2B

Understanding Entity Pages

Summary

Wiki Pages (11)

KAT2B — Lysine Acetyltransferase 2B

Epigenetic Dysregulation in Neurodegeneration

Lactate Lactylation in Neurodegeneration

KAT2A (Lysine Acetyltransferase 2A)

Autism Spectrum Disorder

KAT8 Gene

KAT5 Protein — Lysine Acetyltransferase 5 (TIP60)

EP300 Gene

KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)