🎯 Drug Targets

Browse 3 drug targets with druggability analysis, composite scores, and clinical context

3

Targets

3

High Druggability

0.70

Avg Score

15

Target Classes

Druggability Distribution

High: 3Medium: 0Low: 0Unknown: 0

Avg druggability score: 0.867

Clinical Pipeline

Approved: 2Phase III: 0Phase II: 1Phase I: 0Preclinical: 0

Total compounds: 8 · Approved: 4

Filtered by: class=ion_channel, druggability=High — 3 results

GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 Phase 4

Ion Channel High Druggability

GABRA1 mediates inhibitory neurotransmission through GABA-A receptor subunit composition, modulating neuronal excitability and synaptic signaling. In neurodegeneration contexts, alterations in GABRA1 expression or function can contribute to neuronal hyperexcitability, oxidative stress, and potentially accelerated cellular damage mechanisms associated with progressive neurological disorders.

CACNA1G Voltage-dependent T-type calcium channel subunit a Phase 4

Ion Channel High Druggability

Small molecule blocker of T-type calcium channel activity

P2RX7 P2X purinoreceptor 7 Phase 2

Ion Channel High Druggability

Selective P2X7 receptor antagonists blocking ATP-gated ion channel