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🎯 Drug Targets

Browse 7 drug targets with druggability analysis, composite scores, and clinical context

7
Targets
0
High Druggability
0.68
Avg Score
15
Target Classes
Druggability Distribution
High: 0Medium: 7Low: 0Unknown: 0
Avg druggability score: 0.590
Clinical Pipeline
Approved: 7Phase III: 0Phase II: 0Phase I: 0Preclinical: 0
Total compounds: 27 · Approved: 13
Class All Classes Enzyme (35) Signaling Protein (25) Structural Protein (17) Protein (16) Gpcr (13) Ion Channel (12) Transcription Factor (11) Receptor (11) Ligand (10) Transporter (8) Epigenetic Regulator (8) Kinase (7) Protease (4) Other (4) Chaperone (4)
Druggability All Druggability Low (100) Medium (62) High (14) Undruggable (6) other (3)
Sort Score Druggability Gene A-Z Market Price
Filtered by: class=GPCR, druggability=Medium — 7 results
MTNR1A Melatonin receptor 1A Phase 4
Gpcr Medium Druggability
Score
0.74
Drug.
0.57
Safety
0.80
Drugs
3
Hyps
2
Papers
48
Small molecule agonists that activate G-protein coupled receptor signaling
ADORA2A Adenosine A2A receptor Phase 4
Gpcr Medium Druggability
Score
0.69
Drug.
0.57
Safety
0.70
Drugs
12
Hyps
1
Papers
31
Small molecule antagonists blocking adenosine A2A receptor signaling
ADRA2A Alpha-2A adrenergic receptor Phase 4
Gpcr Medium Druggability
Score
0.68
Drug.
0.59
Safety
0.60
Drugs
2
Hyps
1
Papers
31
Small molecule agonists and antagonists modulating noradrenergic signaling
GLP1R Glucagon-like peptide-1 receptor Phase 4
Gpcr Medium Druggability
Score
0.67
Drug.
0.64
Safety
0.80
Drugs
3
Hyps
1
Papers
0
GLP-1 receptor agonist peptides and small molecule modulators
HCRTR1 Hypocretin Receptor 1 Phase 4
Gpcr Medium Druggability
Score
0.66
Drug.
0.60
Safety
0.70
Drugs
2
Hyps
3
Papers
26
Small molecule antagonist blocking orexin receptor signaling
P2RY12 P2Y purinoreceptor 12 Phase 4
Gpcr Medium Druggability
Score
0.66
Drug.
0.55
Safety
0.50
Drugs
3
Hyps
6
Papers
44
P2Y12 receptor antagonists blocking ADP-mediated signaling
HCRTR2 Hypocretin Receptor 2 Phase 4
Gpcr Medium Druggability
Score
0.65
Drug.
0.60
Safety
0.70
Drugs
2
Hyps
3
Papers
57
Small molecule antagonist blocking orexin receptor signaling
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