| Gene Symbol | IDH2 |
| Chromosome | 15q26.1 |
| Protein Type | Gene |
| Target Class | Enzyme |
| Function | Isocitrate dehydrogenase 2 (IDH2) is a mitochondrial enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG), producing NADPH in the mitochondrial matrix. |
| Mechanism of Action | Small molecule inhibitor of mutant IDH2 enzyme activity |
| Subcellular Localization | the mitochondrial matrix, where it plays essential roles in both energy production and cellular redox homeostasis. The e |
| Druggability | High (0.90) |
| Clinical Stage | Approved |
| Pathways | Calcium Signaling, Circadian Rhythm, Complement, Epigenetic, Glycolysis |
| UniProt ID | P00342 |
| GeneCards | IDH2 |
| Human Protein Atlas | IDH2 |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Enasidenib, Ivosidenib |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Grid Cell-Specific Metabolic Reprogramming via IDH |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |