Contents

MT1B (MTNR1B) Receptor Neurons

🔬 Protein Info

Gene Symbol	ent-gene-93f521e9
Chromosome	11
Function	### Circadian Rhythm Regulation
Retina	MTNR1B is expressed in retinal neurons, where it contributes to phototransduction and circadian visual processing.
Hypothalamus	MTNR1B neurons in hypothalamic regions regulate metabolic functions and sleep.
Pancreatic beta cells	MTNR1B expression in pancreatic islets links melatonin to glucose regulation.
Adipose tissue	MTNR1B in adipocytes modulates lipid metabolism and energy balance.
MTNR1B gene	Located on chromosome 11, encodes a 362-amino acid GPCR
Signal transduction	Couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels
Ligand affinity	High affinity for melatonin (Kd ~ 10-100 pM)
Expression pattern	Species-specific expression patterns in brain and peripheral tissues
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph