| Gene Symbol | ADAMTS13 |
| Full Name | A Disintegrin And Metalloproteinase with Thrombospondin Motifs 13 |
| Chromosome | 9q34.2 |
| Protein Type | Protease |
| Function | ADAMTS13 is a zinc-dependent metalloprotease that specifically cleaves von Willebrand factor (VWF) multimers into smaller, less pro-thrombotic units. |
| Primary Expression | the liver, particularly by hepatic stellate cells and endothelial cells [2] |
| UniProt ID | https://www.uniprot.org/uniprot/Q76LX8 Q76LX8 |
| Ensembl ID | ENSG00000162825 |
| GeneCards | ADAMTS13 |
| Human Protein Atlas | ADAMTS13 |
| Liver | Primary site of synthesis (hepatocytes and hepatic stellate cells) |
| Brain | Cerebral microvascular endothelial cells, astrocytes |
| Kidney | Glomerular endothelial cells |
| Plasma | Circulating enzyme at concentrations of ~1 μg/mL |
| Recombinant ADAMTS13 | Being developed for congenital TTP; potential neuroprotective therapy |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!