| Gene Symbol | ent-gene-6900b2bc |
| Extracellular matrix (ECM) remodeling | ADAMTS-4 cleaves aggrecan and other proteoglycans (versican, brevican, neurocan) in the ECM, facilitating tissue remodeling during development and repair |
| Perineuronal net (PNN) degradation | Cleaves brevican and other chondroitin sulfate proteoglycans (CSPGs) that form PNNs, structures critical for synaptic stability and neural plasticity |
| Amyloid-beta clearance | Identified as an amyloid-beta (Aβ)-degrading enzyme that can cleave Aβ peptides, potentially contributing to amyloid homeostasis in the brain |
| Neuroinflammatory modulation | Expression is upregulated in reactive astrocytes and microglia during neuroinflammation |
| Spinal cord plasticity | Promotes axonal regeneration and plasticity after spinal cord injury by degrading inhibitory CSPGs |
| Amyloid-beta degradation | ADAMTS-4 cleaves Aβ at multiple sites within the peptide, representing a novel Aβ-degrading pathway complementary to neprilysin and insulin-degrading enzyme |
| Protective variant mechanism | The protective I72V variant increases ADAMTS-4 enzymatic activity, enhancing Aβ clearance and reducing amyloid plaque burden in mouse models |
| Perineuronal net disruption | Dysregulated ADAMTS-4 activity in AD may contribute to PNN breakdown, destabilizing synaptic connections and accelerating tau pathology spread |
| Reactive astrocyte expression | ADAMTS4 is highly upregulated in disease-associated astrocytes surrounding amyloid plaques, suggesting a role in the glial response to Aβ deposition |
| High expression | Cerebral cortex, hippocampus (particularly CA1 and dentate gyrus), striatum |
| Moderate expression | Thalamus, cerebellum, brainstem, spinal cord |
| Cellular expression | Primarily astrocytes, with lower expression in neurons and oligodendrocytes |
| Disease-state upregulation | Dramatically increased in reactive astrocytes near amyloid plaques in AD brain tissue |
| Subcellular localization | Secreted enzyme; localized to the extracellular space and cell surface |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!