| Gene Symbol | ADAMTS4 |
| Protein Type | Protease |
| Function | ADAMTS4 encodes a member of the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin motifs) family of secreted zinc metalloproteinases. |
| Subcellular Localization | Secreted enzyme; localized to the extracellular space and cell surface |
| Exons | 8 |
| Pathways | Circadian Rhythm, Tgf-Β, TGF-beta signaling |
| Ensembl ID | ENSG00000158859 |
| GeneCards | ADAMTS4 |
| Human Protein Atlas | ADAMTS4 |
| Extracellular matrix (ECM) remodeling | ADAMTS-4 cleaves aggrecan and other proteoglycans (versican, brevican, neurocan) in the ECM, facilitating tissue remodeling during development and repair |
| Perineuronal net (PNN) degradation | Cleaves brevican and other chondroitin sulfate proteoglycans (CSPGs) that form PNNs, structures critical for synaptic stability and neural plasticity |
| Amyloid-beta clearance | Identified as an amyloid-beta (Aβ)-degrading enzyme that can cleave Aβ peptides, potentially contributing to amyloid homeostasis in the brain |
| Neuroinflammatory modulation | Expression is upregulated in reactive astrocytes and microglia during neuroinflammation |
| Spinal cord plasticity | Promotes axonal regeneration and plasticity after spinal cord injury by degrading inhibitory CSPGs |
| Amyloid-beta degradation | ADAMTS-4 cleaves Aβ at multiple sites within the peptide, representing a novel Aβ-degrading pathway complementary to neprilysin and insulin-degrading enzyme |
| Associated Diseases | Alzheimer's Disease (AD |
| Interactions | SMAD3, BMAL1, Rb, BIN1, AGING, AND |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |