| Gene Symbol | ADRA2CADRENERGIC |
| Aliases | ADRA2CADRENERGIC |
| Function | α2-adrenergic involvement in REM behavior disorder |
| Subcellular Localization | ** | Plasma membrane, G-protein coupled receptor | |
| N-terminal extracellular domain | Short, glycosylated sequence involved in receptor folding and ligand binding |
| Seven transmembrane helices (TM1-TM7) | Form the ligand-binding pocket and G-protein interface |
| Three extracellular loops (ECL1-ECL3) | Contain key residues for ligand recognition |
| Three intracellular loops (ICL1-ICL3) | Coupling domain for G-protein interaction |
| C-terminal cytoplasmic domain | Involved in receptor desensitization and trafficking |
| Clonidine | Mixed α2-adrenergic agonist, used as antihypertensive and analgesic |
| Guanfacine | Selective α2A agonist, approved for ADHD treatment |
| Dexmedetomidine | Highly selective α2 agonist, used in sedation |
| Medetomidine | Veterinary sedative with α2 agonist activity |
| Yohimbine | α2-selective antagonist, used in research and erectile dysfunction |
| Idazoxan | Non-selective α2 antagonist |
| Atipamezole | Selective α2 antagonist, medetomidine reversal |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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