| Gene Symbol | ent-gene-5787d5b9 |
| Chromosome | 7q36.1 |
| Function | ### Autophagosome Formation |
| Six transmembrane helices | Spanning the membrane multiple times |
| N-terminal cytosolic domain | Contains linear sorting motifs |
| C-terminal cytosolic domain | Functions in protein-protein interactions |
| Lumenal loops | Form the core of the autophagosome |
| MIT domain | Microtubule-interacting and transport domain |
| LC3-interacting region (LIR) | Binds LC3/GABARAP family proteins |
| Phosphorylation sites | Multiple serine/threonine residues for regulation |
| Macroautophagy | Bulk degradation of cytoplasmic components |
| Selective autophagy | Receptor-mediated degradation of specific cargoes |
| ER-phagy | Endoplasmic reticulum turnover |
| Mitophagy | Mitochondrial quality control |
| Brain | Regulates neuronal autophagy, relevant to neurodegenerative diseases |
| Liver | Controls hepatic autophagy and metabolism |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!