| Gene Symbol | ent-gene-8ccd65fc |
| Function | The Na+/K+-ATPase is an essential electrogenic pump that maintains the resting membrane potential and regulates cellular volume |
| Ion Transport | Active transport of 3 Na+ out and 2 K+ into neurons per ATP hydrolyzed |
| Membrane Potential | Establishes and maintains the neuronal resting membrane potential (-70 to -90 mV) |
| Secondary Transport | Powers secondary active transporters including glutamate transporters |
| Calcium Regulation | Indirectly affects calcium homeostasis through Na+/Ca2+ exchangers |
| Neuronal Signaling | Critical for action potential generation and propagation |
| Neurotransmitter Cycling | Essential for Na+-dependent neurotransmitter reuptake |
| Basal Ganglia | High expression in striatum (caudate/putamen), globus pallidus, substantia nigra |
| Thalamus | High expression in thalamic nuclei |
| Brainstem | Prominent expression in brainstem nuclei |
| Cerebellum | Purkinje cells and deep cerebellar nuclei |
| [Cortex](/brain-regions/cortex) | Layer 5 pyramidal neurons |
| Basal ganglia | Very high expression in striatum and globus pallidus |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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