| Gene Symbol | ent-gene-108079b2 |
| Chromosome | 10q11.21. |
| Elevated levels | Significantly elevated in CSF and plasma of MS patients during relapses |
| Disease correlation | Levels correlate with cognitive decline measured by MMSE and disease severity |
| Pathology association | Associated with amyloid-beta plaque deposition and neurofibrillary tangles |
| Neuroinflammatory role | Mediates Aβ-induced neuroinflammation through microglial activation |
| Therapeutic target | Exogenous CXCL12 administration shows neuroprotective effects in animal models |
| CSF elevation | Increased CXCL12 in CSF of PD patients, particularly in early stages |
| Progression marker | Associated with neuroinflammation severity and disease progression rate |
| Neuroprotection | Regulates dopaminergic neuron survival through CXCR4-mediated signaling |
| α-Synuclein interaction | May influence α-synuclein pathology and aggregation |
| Motor symptom correlation | Levels correlate with UPDRS motor scores |
| Rapid upregulation | CXCL12 increases within hours following ischemic injury |
| Inflammatory recruitment | Mediates inflammatory cell recruitment to the injury site |
| Regenerative effects | Promotes neurogenesis and angiogenesis in the peri-infarct region |
| Prognostic value | Higher levels associate with faster disease progression and shorter survival |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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