biomarker 893 words KG: ent-gene-6e1f0bee 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

GDNF - Neurotrophic Factor Biomarker

🔬 Protein Info
Gene SymbolGDNF
Full NameNeurotrophic Factor Biomarker
AliasesGlial Cell Line-Derived Neurotrophic Factor
Protein FamilyGDNF family (TGF-β superfamily)
FunctionDopaminergic/Motor neuron survival, neurite outgrowth
Primary ExpressionSecreted, Extracellular space
Subcellular LocalizationSecreted, Extracellular space
Molecular Weight15-20 kDa (dimeric)
PathwaysPI3K, MAPK, TGF-β
UniProt IDP39905
GeneCardsGDNF
Human Protein AtlasGDNF
GeneGDNF
ProteinGlial Cell Line-Derived Neurotrophic Factor
ReceptorsGFRα1/RET, GFRα2/RET, GFRα3/RET
Associated DiseasesALS, APOPTOSIS, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compoundslevodopa, trehalose, rapamycin
InteractionsGFRAL, BDNF, GLP1R, SHH, ADCY3, LMX1A
SciDEX HypothesesGDNF Gradient Establishment by Schwann Cells Enabl
KG Connections782 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Glial Glycocalyx Remodeling Therapy
Score: 0.41
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.41

Related Analyses (8)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (5)

Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-6e1f0bee data_in benchmark_ot_ad_answer_key:GDNF
benchmark_ot_ad_answer_key:GDNF data_in ent-gene-6e1f0bee