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Biomarker: Microglial Proteins in CSF Reveal AD Progression States
biomarker
2,643 words
KG: MICROGLIALCSFPROTEINSADSTAGING
2026-03-25
kind:biomarker
section:biomarkers
state:published
Contents
Microglial Proteins in CSF Reveal AD Progression States
🔬
Protein Info
Gene Symbol
MICROGLIALCSFPROTEINSADSTAGING
Summary
Comprehensive review of CSF microglial proteins that distinguish Alzheimer's disease stages from preclinical to dementia
Databases
GeneCards
UniProt
NCBI Gene
HPA
STRING
Knowledge Graph
Related Hypotheses (24)
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.49
TREM2-Dependent Microglial Senescence Transition
Score: 0.83
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.65
Retinal Vascular Microcirculation Rescue
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.62
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.61
TREM2-mediated microglial tau clearance enhancement
Score: 0.58
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.58
APOE Isoform Expression Across Glial Subtypes
Score: 0.57
APOE-TREM2 Interaction Modulation
Score: 0.57
Lysosomal Enzyme Trafficking Correction
Score: 0.56
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.56
Orexin-Microglia Modulation Therapy
Score: 0.56
Lysosomal Calcium Channel Modulation Therapy
Score: 0.56
Microglial Purinergic Reprogramming
Score: 0.55
Lysosomal Membrane Repair Enhancement
Score: 0.52
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.52
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.52
Lysosomal Positioning Dynamics Modulation
Score: 0.51
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.50
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.47
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.46
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.43
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.61
Show 19 more
Related Analyses (18)
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Show 13 more
Related Experiments (3)
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40