| US Medicare Data | Analysis of elderly beneficiaries revealed that cancer survivors had a 30-40% reduced incidence of AD compared to age-matched populations without cancer history. |
| Parkinson's Disease Cohorts | Multiple studies have documented reduced cancer prevalence among PD patients, particularly for melanoma, prostate, and colorectal cancers. |
| Cell Cycle Regulation | Dysregulated cell cycle control is a hallmark of cancer, while inappropriate cell cycle re-entry in neurons leads to death in AD |
| Apoptosis Pathways | Common dysregulation of apoptosis in both conditions |
| Autophagy-Lysosomal System | Impaired autophagy in neurodegeneration vs. altered autophagy in cancer |
| Cancer Immune Surveillance | Active immune surveillance helps prevent tumors |
| Neuroinflammation | Chronic neuroinflammation drives neurodegeneration |
| Mitochondrial Dysfunction | Present in most neurodegenerative diseases and many cancers |
| Oxidative Stress | Both conditions involve significant oxidative damage |
| Insulin Signaling | Diabetes is a risk factor for both AD and certain cancers |
| Cancer | Often involves upregulation of protein synthesis machinery |
| Neurodegeneration | Characterized by protein misfolding and aggregation |
| Databases | OMIMOrphanetClinicalTrialsPubMed |