Contents

Circadian Rhythm Dysfunction in CBS/PSP

Disease Info

Reduced melatonin amplitude	PSP patients show significantly lower nocturnal melatonin levels compared to healthy controls[@mishima1999]
Phase advance	Melatonin onset occurs earlier in PSP patients, contributing to early-morning awakenings
Blunted rhythms	The normally sharp nocturnal rise in melatonin is dampened or absent in advanced disease
Databases	OMIM Orphanet ClinicalTrials PubMed

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