| Gene Symbol | ent-gene-679b721f |
| Chromosome | 7q31 |
| Subcellular Localization | key brain regions: [@zhang2022] |
| Molecular Weight | ~50 kDa |
| Gene Location | Chromosome 7q31 |
| Protein Length | 462 amino acids |
| Structure | Seven-transmembrane domain architecture typical of GPCRs |
| N-glycosylation sites | Multiple extracellular Asn residues for proper folding |
| Expression pattern | Highest in substantia nigra pars compacta (SNc), striatum, and frontal cortex |
| Endogenous ligands | Originally thought to be endothelin-like peptides (uridine, adenosine) |
| Orphan status | Historically classified as an orphan receptor; emerging evidence suggests it may function as a chemokine-like receptor |
| G protein coupling | Primarily Gi/Go-coupled, inhibiting adenylate cyclase |
| β-arrestin recruitment | Demonstrates β-arrestin-dependent signaling |
| Nigrostriatal pathway | SNc GPR37 neurons project to striatum |
| Mesocorticolimbic system | Ventral tegmental area to prefrontal cortex |
| Cortico-striatal loops | Motor and associative loops |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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