| Gene Symbol | ent-gene-8cd44c77 |
| Function | Mechanism |
| Taxonomy | ID |
| Cell Ontology (CL) | CL:4072017 |
| Location | Arcuate nucleus, mediobasal hypothalamus |
| Coordinates | Approximately A-P: -2.3 to -2.8 mm from bregma |
| Cell Numbers | ~10,000-15,000 neurons in mouse ARC |
| Primary Neurotransmitters | NPY, AgRP, GABA |
| Key Markers | NPY, AgRP, Y1R, Y2R, MC4R (AgRP antagonist) |
| Glucose Homeostasis | Modulate hepatic glucose production |
| Lipid Metabolism | Regulate lipogenesis and lipolysis |
| Insulin Sensitivity | Influence peripheral insulin action |
| Bone Metabolism | Modulate bone formation through sympathetic output |
| Target | Approach |
| Y1R Antagonists | Block orexigenic signaling |
| Y2R Agonists | Inhibit NPY release |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |