| Prognostication | Different subtypes have varying disease trajectories |
| Diagnostic accuracy | Subtype features guide differential diagnosis |
| Therapeutic development | Subtype-specific biomarkers for clinical trials |
| Personalized medicine | Tailored management strategies |
| Corticotopic (CBD) pathology | Classic 4R tauopathy with astrocytic plaques |
| Coexisting TDP-43 | Approximately 30-40% of cases show TDP-43 co-pathology |
| MRI | Asymmetric frontoparietal cortical atrophy, particularly in premotor and primary motor cortex |
| FDG-PET | Hypometabolism in asymmetric frontoparietal regions |
| Tau PET | Increased uptake in motor cortex and basal ganglia |
| Richardson's syndrome features | Many patients meet criteria for both CBS-PAGF and PSP-RS |
| Subcortical tau burden | More prominent subcortical involvement than classic CBS |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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