| Infantile NCL (CLN1) | Onset at 6-24 months |
| Late Infantile NCL (CLN2) | Onset at 2-4 years |
| Juvenile NCL (CLN3) | Onset at 5-10 years (most common form) |
| Adult NCL (CLN4) | Onset in adolescence or adulthood |
| Progressive dementia | Memory loss, cognitive decline, learning difficulties |
| Motor deterioration | Ataxia, spasticity, dystonia, loss of coordination |
| Seizures | Typically generalized tonic-clonic or myoclonic seizures |
| Visual impairment | Progressive retinal degeneration leading to blindness |
| Premature death | Usually within the second or third decade |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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