disease 1,074 words KG: ent-dise-cc067db4
Contents

Drug-Induced Parkinsonism

Disease Info
Prevalence10-20% of all parkinsonism cases
IncidenceEstimated 0.5-1 per 1000 per year in exposed population
Age of onsetTypically 50-70 years
Sex ratioFemale predominance (1.5:1)
Time to onsetUsually 2 weeks to 12 months after drug initiation
FlunarizineCalcium channel blocker, used for migraine
CinnarizineSimilar to flunarizine
ReserpineAntihypertensive (historical)
MethyldopaAntihypertensive (historical)
BradykinesiaSlowness of movement, decreased spontaneous activity
RigidityIncreased muscle tone, "lead-pipe" quality, often with cogwheeling
Resting tremor4-6 Hz "pill-rolling" tremor
DatabasesOMIMOrphanetClinicalTrialsPubMed

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