| Bradykinesia | Progressive slowing of voluntary movements |
| Rigidity | Lead-pipe rigidity with cogwheeling |
| Resting Tremor | Typically less prominent than in classic Parkinson's Disease |
| Gait Disturbances | Shuffling gait with postural instability |
| Festination | Short, shuffling steps |
| Muscle Weakness | Progressive limb weakness, typically beginning in the distal muscles |
| Muscle Atrophy | Wasting of affected muscle groups |
| Fasciculations | Involuntary muscle twitches |
| Hyperreflexia | Exaggerated deep tendon reflexes |
| Bulbar Symptoms | Dysphagia, dysarthria, and eventual respiratory failure<sup>[7]</sup> |
| Executive Dysfunction | Impaired planning, reasoning, and judgment |
| Memory Impairment | Particularly affecting recent memory |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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