disease 866 words KG: ent-dise-e18a5ecf 2026-03-29
kind:diseasesection:diseasestopic:huntingtons
Contents

Juvenile Huntington's Disease

Disease Info
InheritanceAutosomal dominant
CAG Repeat Threshold>60 repeats (classic JHD definition); sometimes >55 in broader definitions
Parental Origin~80% paternal (vs ~50% in adult HD)
AnticipationStrong; longer repeats expand more during spermatogenesis
Chromosome4p16.3 (HTT gene)
ProteinHuntingtin (3,142 amino acids)
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (3)

Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.48

Related Analyses (17)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived